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KRAS G12C inhibitor 11

CAS No. 2158297-63-1

KRAS G12C inhibitor 11( —— )

Catalog No. M13445 CAS No. 2158297-63-1

KRAS G12C inhibitor 11 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    KRAS G12C inhibitor 11
  • Note
    Research use only, not for human use.
  • Brief Description
    KRAS G12C inhibitor 11 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C.
  • Description
    KRAS G12C inhibitor 11 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC50 of 5 nM; demonstrates super proportional dose ascending oral exposure in mice with 3h target coverage at the 30 mg/kg dose; shows rapid growth inhibition and durable efficacy even after dosing was stopped, orally active.
  • In Vitro
    Kirsten Rat Sarcoma 2 Viral Oncogene Homolog (KRas) is a small GTPase and a member of the Ras family of oncogenes. KRas serves a molecular switch cycling between inactive (GDP -bound) and active (GTP -bound) states to transduce upstream cellular signals received from multiple tyrosine kinases to downstream effectors to regulate a wide variety of processes, including cellular proliferation.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    Ras
  • Recptor
    Ras
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2158297-63-1
  • Formula Weight
    551.695
  • Molecular Formula
    C32H37N7O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CN1CCCC1COC2=NC3=C(CCN(C3)C4=CC=CC5=CC=CC=C54)C(=N2)N6CCN(C(C6)CC#N)C(=O)C=C
  • Chemical Name
    2-((S)-1-acryloyl-4-(2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(naphthalen-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-2-yl)acetonitrile

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. U.S. Pat. Appl. Publ. (2018), US 20180072723 A1 20180315.
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